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Web address: http://140.135.61.250/vips/

Web Name: VIPS

Authors:

1.  Dr. Chung-Yung Chen

Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, 320, Taiwan

cychen@cycu.edu.tw

 

2.  Jun-Jie Hong

Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, 320, Taiwan

hgj2368@hotmail.com

 

3.  Dr. Tzong-Yuan Wu

Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, 320, Taiwan

tywu@cycu.edu.tw

 

4.  Dr. Tsair-Yuan Chang

Information Management Department, Ming Chuan University, Taoyuan County, 333, Taiwan

tychang@mail.mcu.edu.tw

 

 

Sequences used in VIPS system

 

Positive group (from Rfam database): Cripavirus IRES sequences, HCV IRES sequences, EMCV IRES sequences, PV IRES sequences.

 

Negative group (from NCBI nucleotide database): CrPV complete genome sequence, HCV gene sequences, EMCV gene sequences, PV gene sequences.

 

Training data: positive group,negative group, human UTR sequences, Virus genome sequences, 48717 sequencing including known IRES element of non-IRES sequencs in total.

 

 

VIPS system

 

Group 1 IRES (CrPV): specificity = 97.06%, sensitivity = 100%, precision = 97.37%

 

Group 2 IRES (HCV): specificity = 100%, sensitivity = 81.59%, precision = 83.77%

 

Group 3 IRES (EMCV): specificity = 100%, sensitivity = 64.71%, precision = 89.83%

 

Group 4 IRES (PV): specificity = 98.37%, sensitivity = 62.44%, precision = 93.83%